CHEMISTRY 781: Nuclear Magnetic Resonance Spectroscopy: Theory and Practice

Syllabus

Chem781 Syllabus

Tentative Course outline

Course Outline

Lecture notes (PDF format)

1. Part I: Basic theory (3 lectures)
2. Part II: The spectrometer (2 lectures) 
3. Part III: The chemical shift (2 lectures) 
4. Part IV: Spin-spin coupling (2 lectures)
5. Part V: Multiple pulse experiments and double resonance (3 lectures)
6. Part VI: Two dimensional NMR – basic theory and through bond correlation
7. Part VII: COSY spectra and coupling constants
8. Part VIII: NOE and through space correlation
9. Part IX: Relaxation, dynamics and Special Methods

Powerpoint Presentations (PPTX format)

• chem781_part1+2
• chem781_part3
• chem781_part4
• chem781_part5
• chem781_part6
• chem781_part7
• chem781_part8
• chem781_part9

Handouts

1. Fundamental Constants
2. Table of NMR active nuclei (2 pages)
3. Summary of important equations of part I and II
4. Schematics of Magnet, Console and Probe (3 pages)
5. 1H and 13C chemical shift ranges
6. Examples of 1H and 13C NMR chemical shifts
7. Tables with proton chemical shift substituent increments
8. Tables with C-13 chemical shift substituents increments (2 pages)
9. Tables with 1H/1H coupling constants (2 pages)
10. Assignment using HSQC/COSY/(INADEQUATE): Example Menthol (7 pages)
11. Structure elucication using HSQC/COSY/HMBC: Example Camphour (5 pages)
12. Abundance vs. Sensitivity of Nuclei (4 pages)