Publications

Dr. Frick’s edited book on estrogens and memory available at Amazon, Barnes & Noble, or the Oxford University Press website!

For Frick lab articles, see below or search PubMed

  • Frick, K.M., Fleischer, A.W., Schwabe, M.R., Abdelazim, F.A., Sem, D.S., Donaldson, W.A. (2025) Not your mother’s hormone therapy: Highly selective estrogen receptor beta agonists as next generation therapies for menopausal symptom relief. Hormones and Behavior, 173, 105773. PDF.
  • Schwabe, M.R., Fleischer, A.W., Kuehn, R.K., Chaudhury, S., Donaldson, W.A., Sem, D.S., York, J.M., LaDu, M.J., Frick, K.M. (2024) The novel estrogen receptor beta agonist EGX358 and APOE genotype influence memory, vasomotor, and anxiety outcomes in an Alzheimer’s mouse model. Frontiers in Aging Neuroscience, 16, 1477045. PDF
  • Beamish, S.B., Tuscher, J.J., and Frick, K.M. (2024) Memory and epigenetics: Influence of sex and estrogens. In: Reference Module in Biomedical Sciences (Elsevier 2024). To be included in Encyclopedia of Endocrine Diseases, 3rd Edition in February 2026. PDF
  • Taxier, L.R., Pillerová, M., Branyan, T.E., Sohrabji, F., Frick, K.M. (2024). The astrocytic glutamate transporter GLT-1 is essential for the memory-enhancing effects of 17β-estradiol in ovariectomized mice. Hormones and Behavior, 165, 105618. PDF
  • Machado, G.D.B., Schnitzler, A.L., Fleischer, A.W., Beamish, S.B., Frick, K.M. (2024). G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice. Hormones and Behavior, 161, 105516. PDF
  • Chanana, V., Hackett, M., Deveci, N., Aycan, N., Ozaydin, B., Sena Cagatay, N., Hanalioglu, D., Kintner, D.B., Corcoran, K., Yapici, S., Camci, F., Eickhoff, J., Frick, K.M., Ferrazano, P., Levine, J.E., Cengiz, P. (2024). TrkB-mediated sustained neuroprotection is sex specific and ERα dependent in adult mice following neonatal hypoxic ischemia. Biology of Sex Differences, 15, 1. PDF
  • Fleischer, A.W. and Frick, K.M. (2023). New perspectives on sex differences in learning and memory. Trends in Endocrinology and Metabolism, 34(9), 526-538. PDF
  • Boyd, H.M., Frick, K.M., Kwapis, J.L. (2023). Connecting the dots: Potential interactions between sex hormones and the circadian system during memory consolidation, Journal of Biological Rhythms, 0 10.1177/07487304231184761. PDF
  • Pillerová, M., Pastorek, M., Borbélyová, V., Riljak, V., Frick, K.M., Hodosy, J., Tóthová, L. (2022) Sex steroid hormones in depressive disorders as a basis for new potential treatment strategies. Physiological Research, 71(S2), S187-S202. PDF
  • Beamish, S.B., Gross, K.S., Anderson, M.M., Helmstetter, F.J., and Frick, K.M. (2022). Sex differences in training-induced protein degradation in the dorsal hippocampus and medial prefrontal cortex of male and female mice. Learning and Memory, 29(9), 302-311. PDF
  • Pillerová, M., Borbélyová, V., Pastorek, M., Riljak, V., Hodosy, J., Frick, K.M., Tóthová, L. Molecular actions of sex hormones in the brain and their potential treatment use in anxiety disorders. Frontiers in Psychiatry, 13, 972158. PDF
  • Pillerová, M., Borbélyová, V., Hodosy, J., Riljak, V., Renczés, E., Frick, K.M., Tóthová, L. (2021). On the role of sex steroids in biological functions by classical and non-classical pathways. An update. Frontiers in Neuroendocrinology, 62, 100926. PDF
  • Taxier, L.R., Philippi, S.M., Fleischer, A.W., York, J.M., LaDu, M.J., and Frick, K.M. (2022). APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer’s disease. Neurobiology of Aging, 118, 13-24. PDF
  • Gross, K.S., Lincoln, C.M., Anderson, M.M., Geiger, G.E., Frick, K.M. (2022). Extracellular matrix metalloproteinase-9 (MMP-9) is required for estradiol enhancement of hippocampal memory consolidation.
    Psychoneuroendocrinology, 141, 105773. PDF
  • Beamish, S.B. and Frick, K.M.(2022). A putative role for ubiquitin-proteasome signaling in estrogenic memory regulation. Frontiers in Behavioral Neuroscience,15, 807215. PDF
  • Taxier, L.R., Philippi, S.M., York, J.M., LaDu, M.J., and Frick, K.M. (2022). APOE4 genotype or ovarian hormone loss influence open field exploration in an EFAD mouse model of Alzheimer’s disease, Hormones and Behavior, 140, 105124. PDF
  • Taxier, L.R., Philippi, S.M., York, J.M., LaDu, M.J., and Frick, K.M. (2022). The detrimental effects of APOE4 on risk for Alzheimer’s Disease may result from altered dendritic spine density, synaptic proteins, and estrogen receptor alpha. Neurobiology of Aging, 112, 74-86. PDF
  • Belayet, J.B., Beamish, S.B., Mizzanoor, M.D., Alanani, S., Ulicki, J., Virdi, R., Frick, D.N., Biswas, S., Rahman, A.F.M.T., Roni, M.S.R., Chen, Y.Q., Steeber, D.A., Frick, K.M., and Hossain, M.M. (2022). Development of a novel, small-molecule brain-penetrant histone deacetylase inhibitor that enhances spatial memory formation in mice. Journal of Medicinal Chemistry, 65(4), 3388-3403. PDF
  • Schwabe, M.R., Lincoln, C.M., Ivers, M.M., and Frick, K.M. (2021). Chemogenetic inactivation of the nucleus reuniens impairs object placement memory in female mice. Neurobiology of Learning and Memory, 185, 107521. PDF
  • Patel, S.A, Frick, K.M., Newhouse, P.A., and Astur, R.S. (2021). Estradiol effects on spatial memory in women. Behavioural Brain Research, 417, 113592. PDF
  • Pillerová, M., Borbélyová, V., Hodosy, J., Riljak, V., Renczés, E., Frick, K.M., Tóthová, L. (2021). On the role of sex steroids in biological functions by classical and non-classical pathways. An update. Frontiers in Neuroendocrinology, 62, 100926. PDF
  • Fleischer, A.W., Schalk, J.C. Wetzel, E., Sem, D.S., Donaldson, W.A., and Frick, K.M. (2021). Long-term oral administration of the novel estrogen receptor beta agonist EGX385 enhances memory consolidation and alleviates drug-induced hot flashes in ovariectomized mice. Hormones and Behavior, 130, 104948. PDF
  • Gross, K.S., Alf, R.L., Polzin, T.R., and Frick, K.M. (2021) 17β-estradiol activation of dorsal hippocampal TrkB is independent of increased mature BDNF expression and is required for enhanced memory consolidation in female mice. Psychoneuroendocrinology, 125, 105110. PDF
  • Taxier, L.R., Gross, K.S., and Frick, K.M. (2020). Oestradiol as a neuromodulator of learning and memory. Nature Reviews Neuroscience, 21, 535-550. PDF
  • Schwabe, M.R., Taxier, L.R., and Frick, K.M. (2020). It takes a neural village: Circuit-based approaches for estrogenic regulation of episodic memory. Frontiers in Neuroendocrinology, 59, 100860. PDF
  • Kim, J., Schalk, J.C., Koss, W.A., Gremminger, R.L., Taxier, L.R., Gross, K.S., Frick, K.M. (2019). Dorsal hippocampal actin polymerization is necessary for activation of G-protein-coupled estrogen receptor (GPER) to increase CA1 dendritic spine density and enhance memory consolidation. Journal of Neuroscience, 39(48), 9598-9610. PDF
  • Taxier, L.R., Philippi, S.M., Fortress, A.M., Frick, K.M. (2019). Dickkopf-1 blocks 17β-estradiol-enhanced object memory consolidation in ovariectomized female mice. Hormones and Behavior, 114, 104545. PDF
  • Yousuf, H., Smies, C.W., Hafenbreidel, M., Tuscher, J.J., Frick, K.M., Mueller, D. (2019). Infralimbic estradiol enhances neuronal excitability and facilitates extinction of cocaine seeking in female rats via a BDNF/TrkB mechanism. Frontiers in Behavioral Neuroscience, 13, 168. PDF
  • Tuscher, J.J., Taxier, L.R., Schalk, J.C., Haertel, J.M., Frick, K.M. (2019) Chemogenetic suppression of medial prefrontal-dorsal hippocampal interactions prevents estrogenic enhancement of memory in female mice.  eNeuro, March/April; 6(2) e0451-18.2019 1-12. PDF
  • Koss, W.A., Frick, K.M. (2019) Activation of androgen receptors protects intact male mice from memory impairments caused by aromatase inhibition.  Hormones and Behavior, 111, 96-104. PDF
  • Tuscher, J.J., Fortress, A.M., Frick, K.M.  (2019). Memory and epigenetics: Role of estrogens.  In: Encyclopedia of Endocrine Diseases, 2ndEdition, Vol. 2, Huhtaniemi, I and Martini, L. (Eds).  New York: Elsevier.  pp. 42-51. PDF
  • Tuscher, J.J., Taxier, L.R., Fortress, A.M., Frick, K.M. (2018). Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice.  Neurobiology of Learning and Memory, 156, 103-116. PDF
  • Koss, W.A., Haertel, J.M., Philippi, S.M., Frick, K.M. (2018). Sex differences in the rapid cell signaling mechanisms underlying the memory-enhancing effects of 17b-estradiol. eNeuro, September/October 2018, 5(5) e0267-18.2018 1–14; https://doi.org/10.1523/ENEURO.0267-18.2018.
  • Hanson, A.M., Perera, K.L.I., Kim, J., Pandey, R.K.,Sweeney, N., Lu, X., Imhoff, A., Mackinnon, A.C., Wargolet, A., Van Hart, R., Frick, K.M., Donaldson, W.A., and Sem, D.S. (2018). A-C estrogens as potent and selective estrogen receptor-beta agonists (SERBAs) to enhance memory consolidation under low-estrogen conditions. Journal of Medicinal Chemistry, 61(11), 4720-4738. PDF
  • Frick, K.M. and Kim, J.  (2018). Mechanisms underlying the rapid effects of estradiol and progesterone on hippocampal memory consolidation in female rodents.  Hormones and Behavior, 104, 100-110. PDF
  • Frick, K.M., Kim, J., Koss, W.A.  (2018). Estradiol and hippocampal memory in males and females.  Current Opinion in Behavioral Sciences, 23, 65-74. PDF
  • Frick, K.M., Tuscher, J.J., Koss, W.A., Kim, J., and Taxier, L.R.  (2018). Estrogenic regulation of memory consolidation:  A look beyond the hippocampus, ovaries, and females.  Physiology and Behavior, 187, 57-66. PDF
  • Sheppard, P., Koss, W.A., Frick, K.M., and Choleris, E. (2018). Rapid actions of estrogens and their receptors on memory acquisition and consolidation in females.  Journal of Neuroendocrinology, 30:e12485. PDF
  • Choleris, E., Galea, L.A.M., Sohrabji, F. and Frick, K.M.  (2018). Sex differences in the brain: Implications for behavioral and biomedical research.  Neuroscience & Biobehavioral Reviews, 85, 126-145. PDF
  • Doncheck, E.M., Urbanik, L.A., DeBaker, M.C., Barron L.M., Liddiard, G.T., Tuscher, J.J., Frick, K.M., Hillard, C.J., Mantsch, J.R.  (2018).  Estrogen potentiates the reinstatement of cocaine seeking in females: role of the prelimbic prefrontal cortex and cannabinoid type-1 receptors. Neuropsychopharmacology, 43(4), 781-790. PDF
  • Kim, J. and Frick, K.M.  (2017).  Distinct effects of estrogen receptor inhibition on object recognition and spatial memory consolidation in ovariectomized mice.  Psychoneuroendocrinology, 84, 110-114. PDF
  • Koss, W.A. and Frick, K.M.  (2017).  Sex differences in hippocampal function.  Journal of Neuroscience Research, 95(1-2), 539-562. PDF
  • Galea, L.A.M., Frick, K.M., Hampson, E., Sohrabji, F., Choleris, E.  (2017).  Why estrogens matter for behavior and brain health.  Neuroscience & Biobehavioral Reviews, 76, 363-379. PDF
  • Kim, J., Szinte, J.S., Boulware, M.I., and Frick, K.M.  (2016). 17β-estradiol and agonism of G-protein Coupled Estrogen Receptor (GPER) enhance hippocampal memory consolidation via different cell-signaling mechanisms.  Journal of Neuroscience, 36(11), 3309-3321.  PDF
  • Tuscher, J.J., Luine, V.N., Frankfurt, M., and Frick, K.M.  (2016).  Estradiol-mediated spine changes in the dorsal hippocampus and medial prefrontal cortex of ovariectomized female mice depend on ERK and mTOR activation in the dorsal hippocampus.  Journal of Neuroscience, 36(5), 1483-1489. PDF
  • Tuscher, J.J., Szinte J.S., Starrett, J.R., Krentzel, A.A., Fortress, A.M., Remage-Healey, L., and Frick, K.M.  (2016). Inhibition of local estrogen synthesis in the hippocampus impairs memory consolidation in ovariectomized female mice.  Hormones and Behavior, 83, 60-67. PDF
  • Fortress, A.M. and Frick, K.M.  (2016).  Hippocampal Wnt signaling: Memory regulation and hormone interactions.  The Neuroscientist, 22(3), 278-294. PDF
  • Frick, K.M., Kim, J., Tuscher, J.J., and Fortress, A.M.  (2015).  Sex steroid hormones matter for learning and memory: estrogenic regulation of hippocampal function in male and female rodents.  Learning and Memory, 22(9), 472-493. PDF
  • Frick, K.M.  Molecular mechanisms underlying the memory-enhancing effects of estradiol.  (2015).  Hormones and Behavior, 74, 4-18. PDF
  • Fortress, A.M., Heisler, J.D., and Frick, K.M. (2015). The mTOR and canonical Wnt signaling pathways mediate the mnemonic effects of progesterone in the dorsal hippocampus. Hippocampus, 25(5), 616-629. PDF
  • Benoit, J.D., Rakic, P., and Frick, K.M. (2015). Prenatal stress induces spatial memory deficits and epigenetic changes in the hippocampus indicative of heterochromatin formation and reduced gene expression. Behavioural Brain Research, 281, 1-8. PDF
  • Tuscher, J.J., Kim, J., Fortress, A.M., and Frick, K.M. (2015). Hormonal regulation of object recognition. Behavioural Brain Research, 285, 140-157. PDF
  • Frick, K.M. (2015). What’s your name again? Effects of estrogens, cognitive stimulation, and exercise on age-related memory loss. F&M Scientist, Winter 2015, 27-53.
  • Fortress, A.M., Kim, J., Poole, R.L., Gould, T.J., and Frick, K.M. (2014). Estradiol-induced epigenetic changes and memory consolidation in middle-aged mice. Learning and Memory, 21(9),457-467. PDF
  • Fortress, A.M. and Frick, K.M. (2014). Epigenetic regulation of estrogen-dependent memory. Frontiers in Neuroendocrinology, 35(4), 530-549. PDF
  • Boulware, M.I., Heisler, J.D., and Frick, K.M. (2013). The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling. Journal of Neuroscience, 33(38), 15184-15194. PDF
  • Fortress, A.M., Schram, S.L., Tuscher, J.J., and Frick, K.M. (2013). Canonical Wnt signaling is necessary for object recognition memory consolidation. Journal of Neuroscience, 33(31), 12619-12626. PDF
  • Fortress, A.M., Fan, L., Orr, P.T., Zhao, Z., and Frick, K.M. (2013). Estradiol-induced object memory consolidation involves dorsal hippocampal mTOR activation. Learning and Memory, 20(3), 147-155. PDF
  • Frick, K.M. (2013). Epigenetics, oestradiol, and hippocampal memory consolidation. Journal of Neuroendocrinology, 25, 1151-1162. PDF
  • Twining R.C., Tuscher, J.J., Doncheck, E.M., Frick, K.M., and Mueller, D. (2013). 17-estradiol enhances expression and extinction of cocaine seeking in female rats. Learning and Memory, 20(6), 300-306. PDF
  • Zhao, Z., Fan, L., Fortress, A.M., Boulware, M.I., and Frick, K.M.  (2012).  Hippocampal histone acetylation regulates object recognition and the estradiol-induced enhancement of object recognition.  Journal of Neuroscience, 32(7), 2344-2351.  PDF
  • Orr, P.T., Rubin, A.J., Fan, L. Kent, B.A., and Frick, K.M. (2012). The progesterone-induced enhancement of object recognition memory consolidation involves activation of the extracellular signal-regulated kinase (ERK) and mammalian target of rapamycin (mTOR) pathways in the dorsal hippocampus. Hormones and Behavior, 61(4), 485-497. PDF
  • Boulware, M.I., Kent, B.A., and Frick, K.M. (in press). The impact of age-related ovarian hormone loss on cognitive and neural function. In: Current Topics in Behavioral Neurosciences: Behavioral Neurobiology of Aging, Pardon, M.-C. and Bondi, M. (Eds). Heidelberg, Germany: Springer-Verlag. PDF
  • Frick, K.M. (2012). Building a better hormone therapy?: How understanding the rapid effects of sex steroid hormones could lead to novel therapeutics for age-related memory decline. Behavioral Neuroscience, 126(1), 29-53. PDF
  • Frick, K.M. (2012). Introduction to the special section on “Hormones and cognition: Perspectives, controversies, and challenges for future research”. Behavioral Neuroscience, 126(1), 1-3. PDF
  • Frick, K.M. and Korol, D.L. (2011). Introduction to the special issue of Neurobiology of Learning and Memory on memory impairment and disease. Neurobiology of Learning and Memory, 96(4), 505-506. PDF
  • Frick, K.M., Zhao, Z., and Fan, L. (2011). The epigenetics of estrogen: Epigenetic regulation of hormone-induced memory enhancement. Epigenetics, 6(6), 675-680. PDF
  • Zhao, Z., Fan, L., and Frick, K.M.  (2010).  Epigenetic alterations regulate estradiol-induced enhancement of memory consolidation. Proceedings of the National Academy of Sciences, USA, 107(12), 5605-5610.  PDF
  • Fan, L., Orr, P.T., Zhao, Z., Chambers, C.H., Lewis, M.C., and Frick, K.M.  (2010).  Estradiol-induced object memory consolidation in middle-aged female mice requires dorsal hippocampal ERK and PI3K activation.  Journal of Neuroscience, 30(12), 4390-4400.  PDF
  • Frick, K.M. and Benoit, J.D.  (2010).  Use it or lose it:  Environmental enrichment as a means to promote successful cognitive aging.  TheScientificWorldJournal, 10, 1129-1141.  PDF
  • Frick, K.M., Fernandez, S.M., and Harburger, L.L.  (2010).  A new approach to understanding the molecular mechanisms through which estrogens affect cognition.  Biochimica et Biophysica Acta, 1800, 1045-1055.  PDF
  • Orr, P.T., Lewis, M.C., and Frick, K.M.  (2009).  Dorsal hippocampal progesterone infusions enhance object recognition in young female mice.  Pharmacology Biochemistry and Behavior, 93(2), 177-182.  PDF
  • Harburger, L.L. Saadi, A. and Frick, K.M.  (2009).  Dose-dependent effects of post-training estradiol plus progesterone treatment on object memory consolidation and hippocampal ERK activation in young ovariectomized mice.  Neuroscience, 160(1), 6-12.  PDF
  • Frick, K.M.  (2009).  Estrogens and age-related memory decline in rodents:  What have we learned and where do we go from here? Hormones and Behavior, 55(1), 2-23.  PDF
  • Pechenino, A.S. and Frick, K.M.  (2009).  Effects of acute 17beta-estradiol treatment on gene expression in the young female mouse hippocampus.  Neurobiology of Learning and Memory, 91, 315-322.  PDF
  • Gresack, J.E., Schafe, G.E., Orr, P.T., and Frick, K.M.  (2009).  Sex differences in contextual fear conditioning are associated with differential ventral hippocampal ERK activation. Neuroscience, 159, 451-467.  PDF
  • Fernandez, S.M., Lewis, M.C., Pechenino, A.S., Harburger, L.L., Orr, P.T., Gresack, J.E., Schafe, G.E., and Frick, K.M.  (2008).  Estradiol-induced enhancement of object memory consolidation involves hippocampal ER activation and membrane-bound estrogen receptors.  Journal of Neuroscience, 28(35), 8660-8667.  PDF
  • Harburger, L.L., Pechenino, A.S., Saadi, A., and Frick, K.M.  (2008).  Post-training progesterone dose-dependently enhances object, but not spatial, memory consolidation.  Behavioural Brain Research, 194, 174-180.  PDF
  • Lewis, M.C., Orr, P.T., and Frick, K.M.  (2008).  Differential effects of acute progesterone administration on spatial and object memory in middle-aged and aged female C57BL/6 mice.  Hormones and Behavior, 54(3), 455-462.  PDF
  • Lewis, M.C., Kerr, K.M., Orr, P.T., and Frick, K.M.  (2008).  Estradiol-induced enhancement of object memory consolidation is dependent on NMDA receptors and protein kinase A in the dorsal hippocampus of female C57BL/6 mice.  Behavioral Neuroscience, 122(3), 716-721.  PDF
  • Bergery-Sweeney, J., Schaevitz, L.R., and Frick, K.M.  (2008).  Neurochemical systems involved in learning and memory.  In: Neurobiology of Mental Illness, 3rd edition.  Charney, D.S., Nestler, E.J., and Bunney, B.S. (Eds.).  New York:  Oxford University Press.  pp. 927-935.
  • Harburger, L.L., Nzerem, C.K., and Frick, K.M.  (2007).  Single enrichment variables differentially reduce age-related memory decline in female mice.  Behavioral Neuroscience, 121(4), 679-699.  PDF
  • Harburger, L.L., Lambert, T.J., and Frick, K.M.  (2007).  Age-dependent effects of environmental enrichment on spatial memory in male mice.  Behavioural Brain Research, 185(1), 43-48.  PDF
  • Gresack, J.E., Kerr, K.M., and Frick, K.M.  (2007b).  Life-long environmental enrichment differentially influences the mnemonic response to estrogen in young, middle-aged, and aged female mice.  Neurobiology of Learning and Memory, 88(4), 393-408. PDF
  • Gresack, J.E., Kerr, K.M., and Frick, K.M.  (2007a).  Short-term environmental enrichment decreases the mnemonic response to estrogen in young, but not aged female mice.  Brain Research, 1160, 91-101.  PDF
  • Harburger, L.L., Bennett, J.C., and Frick, K.M.  (2007).  Effects of estrogen and progesterone on spatial memory consolidation in aged females.  Neurobiology of Aging, 28(4), 602-610.  PDF
  • Frick, K.M.  (2007).  The Neuroscience of Survivor:  Why the “Sole Survivor” Might Have the Most Resilient Brain.  The Psychology of Survivor.  Dallas, TX:  BenBella Books.  pp. 33-46.
  • Gresack, J.E. and Frick, K.M.  (2006b).  Effects of continuous and intermittent estrogen treatments on memory in aging female mice. Brain Research, 1115(1), 135-147.  PDF
  • Gresack, J.E. and Frick, K.M.  (2006a).  Post-training estrogen enhances spatial and object memory consolidation in female mice. Pharmacology Biochemistry and Behavior, 84(1), 112-119.  PDF
  • Bennett, J.C., McRae, P., Levy, L.J., and Frick, K.M.  (2006).  Long-term continuous, but not daily enrichment reduces spatial memory decline in aged male mice.  Neurobiology of Learning and Memory, 85(2), 139-152.  PDF
  • Frick K.M.  (2006).  Estrogen.  In:  The Encyclopedia of Human Development, Vol. 1.  Salkind, N. (Ed).  Thousand Oaks, CA:  Sage Publications.  pp. 473-474.
  • Levy, L.J., Astur, R.S., and Frick, K.M.  (2005).  Men and women differ in object memory, but not performance of a virtual radial maze.  Behavioral Neuroscience, 119(4), 853-862.  PDF
  • Lambert, T.J., Fernandez, S.M., and Frick, K.M.  (2005).  Different types of environmental enrichment have discrepant effects on spatial memory and synaptophysin levels in female mice. Neurobiology of Learning and Memory, 83(3), 206-216.  PDF
  • Gresack, J.E. and Frick, K.M.  (2004).  Environmental factors influence the mnemonic and neural response to estrogen. Neuroscience, 128(3), 459-471.  PDF
  • Fernandez, S.M. and Frick, K.M.  (2004).  Oral estrogen affects memory and neurobiology in middle-aged female mice.  Behavioral Neuroscience, 118(6), 1340-1351.  PDF
  • Frick, K.M., Fernandez, S.M., Bennett, J.C., Prange-Kiel, J., MacLusky, N.J., and Leranth, C.  (2004).  Behavioral training interferes with the ability of gonadal hormones to increase CA1 spine synapse density in ovariectomized female rats.  European Journal of Neuroscience, 19, 3026-3032.  PDF
  • Leranth, C., Prange-Kiel, J., Frick, K.M., and Horvath, T.L.  (2004).  Low CA1 spine synapse density is further reduced by castration in male non-human primates.  Cerebral Cortex, 14, 503-510.  PDF
  • Frick, K.M., Kim, J.J., and Baxter, M.G.  (2004).  Effects of complete cholinergic basal forebrain removal of fear conditioning and spatial learning.  Hippocampus, 14, 244-254.  PDF
  • Bergery-Sweeney, J., Caliguri, E.J., and Frick, K.M.  (2004).  Neurochemical systems involved in learning and memory.  In: Neurobiology of Mental Illness, 2nd edition.  Charney, D.S., Nestler, E.J., and Bunney, B.S. (Eds.).  New York:  Oxford University Press.  pp. 813-820.
  • Frick, K.M. and Gresack, J.E.  (2003).  Sex differences in the behavioral response to spatial and object novelty in adult C57BL/6 mice.  Behavioral Neuroscience, 117(6), 1283-1291.  PDF
  • Gresack, J.E. and Frick, K.M.  (2003).  Male mice exhibit better spatial working and reference memory than females in a water-escape radial arm task. Brain Research, 982, 98-107.  PDF
  • Frick, K.M., Stearns, N.A., Pan, J.-Y., and Berger-Sweeney, J.  (2003).  Effects of environmental enrichment on spatial memory and neurochemistry in middle-aged mice.  Learning and Memory, 10, 187-198.   PDF
  • Frick, K.M. and Fernandez, S.M.  (2003).  Enrichment enhances spatial memory and synaptic plasticity in aged female mice. Neurobiology of Aging, 24, 615-626.   PDF
  • Frick, K.M., Fernandez, S.M., and Bulinski, S.C.  (2002).  Estrogen replacement improves spatial reference memory and increases hippocampal synaptophysin in aged female mice.  Neuroscience, 115(2), 547-558.  PDF
  • Frick, K.M., Burlingame, L.A., Delaney, S.S., and Berger-Sweeney, J.  (2002).  Sex differences in neurochemical markers that correlate with aging in mice.  Neurobiology of Aging, 23, 145-158.   PDF
  • Frick, K.M., and Berger-Sweeney, J.  (2001).  Spatial memory and neocortical neurochemistry vary with the estrous cycle in C57BL/6 mice.  Behavioral Neuroscience, 115(1), 229-237.  PDF
  • Berger-Sweeney, J., Stearns, N.A, Frick, K.M., Beard, B., and Baxter, M.G.  (2000).  The cholinergic basal forebrain is critical for social transmission of food preferences.  Hippocampus, 10, 729-738. PDF
  • Frick, K.M., Stillner, E.T., and Berger-Sweeney, J.  (2000).  Mice are not little rats:  Species differences in a one-day water maze task.  NeuroReport, 11(16), 3461-3465.  PDF
  • Frick, K.M., Burlingame, L.A., Arters, J.A., and Berger-Sweeney, J.  (2000).  Reference memory, anxiety, and estrous cyclicity in C57BL/6NIA mice and affected by age and sex.  Neuroscience, 95(1), 293-307.  PDF
  • Ricceri, L., Usiello, A., Valanzano, A., Calamandrei, G., Frick, K., and Berger-Sweeney, J. (1999).  Neonatal 192 IgG-saporin lesions of basal forebrain cholinergic neurons selectively impair response to spatial novelty in adult rats.  Behavioral Neuroscience, 113(6), 1204-1215.  PDF
  • Frick, K.M. and Bergery-Sweeney, J.  (1999).  Neurochemical systems involved in learning and memory.  In:  Neurobiology of Mental Illness.  Charney, D.S., Nestler, E.J., and Bunney, B.S. (Eds.).  New York:  Oxford University Press.  pp. 685-692.
  • Baxter, M.G., Frick, K.M., Price, D.L., Breckler, S.J., Markowska, A.L., and Gorman, L.K.  (1999).  Presynaptic markers of cholinergic function in the rat brain:  Relationship with age and cognitive status.  Neuroscience, 89(3), 771-780.  PDF
  • Price, D.L., Markowska, A.L., Koliatsos, V.E., Frick, K.M., Borchelt, D.R., Martin, L.J., Kawas, C.H., and Sisodia, S.S.  (1999).  Alzheimer’s disease and animal models.  In:  Neurobiology of Mental Illness.  Charney, D.S., Nestler, E.J., and Bunney, B.S. (Eds.).  New York:  Oxford University Press.  pp. 659-668.
  • Frick, K.M., Price, D.L., Koliatsos, V.E., and Markowska, A.L.  (1997).  The effects of nerve growth factor on spatial recent memory in aged rats persist after discontinuation of treatment. Journal of Neuroscience, 17(7), 2543-2550.  PDF
  • Frick, K.M., Gorman, L.K., and Markowska, A.L.  (1996).  Oxotremorine infusions into the medial septal area of middle-aged rats affect spatial reference memory and ChAT activity. Behavioural Brain Research, 80, 99-109.  PDF
  • Frick, K.M., Baxter, M.G., Markowska, A.L., Olton, D.S., and Price, D.L.  (1995).  Age-related spatial reference and working memory deficits assessed in the water maze.  Neurobiology of Aging, 16(2), 149-160.  PDF
  • Baxter, M.G., Rohrbach, K.W., Tam, S.W., Zaczek, R., Frick, K.M., Golski, S., Wan, R.Q., and Olton, D.S.  (1994)  Effects of linopirdine (DuP 996) and X9121 on age-related memory impairments and on the cholinergic system.  Drug Development Research, 31, 186-196.  PDF
  • Baxter, M.G., Lanthorn, T.H., Frick, K.M., Golski, S., Wan, R.Q., and Olton, D.S.  (1994)  D-Cycloserine, a novel cognitive enhancer, improves spatial memory in aged rats. Neurobiology of Aging, 15(2), 207-213.  PDF
  • Gorman, L.K., Pang, K., Frick, K.M., Givens, B., and Olton, D.S. (1994)  Acetylcholine release in the hippocampus: effects of cholinergic and GABAergic compounds in the medial septal area. Neuroscience Letters, 166, 199-202.  PDF