Karyn Frick and students in the Pearce hall lab
Welcome to the Frick lab!  Our laboratory studies how sex-steroid hormones, aging, and environmental factors affect hippocampal function and hippocampal-dependent memory. Our goal is to identify how these factors affect the cellular and molecular mechanisms underlying memory formation.

Our work is motivated by the rapidly expanding elderly population worldwide, which will greatly increase the prevalence of age-related cognitive decline and dementia. Our ultimate goal is to help mitigate the impact of cognitive aging on the individual and society by facilitating the development of treatments to reduce or prevent age-related memory decline in humans.

Our laboratory uses mice and rats to examine systems-level and cellular-level questions about memory formation in a mammalian system where the effects of aging, hormones, and environmental stimulation are similar to those in humans.  Our studies combine a variety of approaches including behavioral, biochemical, epigenetic, pharmacological, and anatomical methods to pinpoint the molecular mechanisms underlying the effects of estrogens, progestagens, aging, and environmental enrichment on the hippocampus and hippocampal memory formation.

See this short video that provides some context for our research on hormones, aging, and Alzheimer’s disease. This video was produced in association with Dr. Frick’s receipt of a UW System Regent Scholar Award to test the effects of a novel estrogen receptor agonist on memory in a mouse model of Alzheimer’s disease.

Want to join us?  For opportunities at the undergraduate, graduate, and postdoctoral levels, please contact Dr. Frick at frickk@uwm.edu. Undergraduates should complete this fillable form and send it with an unofficial UWM transcript to Dr. Frick at the email address listed above.

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