Staff

Holger Försterling

Chemistry Head ShotsDr. Försterling is the Director of the Nuclear Magnetic Resonance Laboratory, providing NMR services to the department. He is responsible for maintaining the spectrometers, assisting users in conducting experiments, and instructing new users on the use of the instrumentation. In addition, he is implementing new NMR experiments and advising and collaborating with members of the department in the solution of chemical and biochemical problems using NMR spectroscopy .

Dr. Försterling’s areas of personal interest are the study of structure and dynamics of proteins and organometallic complexes using multidimentional NMR methods.

Personal Homepage

Vita Frank Holger Försterling

  • 1986 – 1991
    Study of chemistry at the Philipps Universität Marburg
  • 1991
    Diplomarbeit in the research group of Prof. Berger. Topic: Investigation of the Wittig Reaction with Rapid Injection NMR Spectroscopy
  • 1992 – 1996
    Ph. D. thesis University of Tennessee in Knoxville Advisor: Dr. Craig Barnes Title of Thesis: Synthesis and Fluxional Behavior of Mixed Metal Trinuclear Cluster Complexes of the Cobalt Group.
  • Aug. 1996 – September 1998
    Postdoctoral Studies in the research group of Prof. Griesinger at the Wolfgang Goethe Universität Frankfurt
    Research Project: Structure Determination of Peptide/Calmodulin complexes by multidimensional NMR spectroscopy
  • October 1998 – present
    Director of NMR facilities, University of Wisconsin-Milwaukee
  • 2000 – 2016
    Secretary of the Milwaukee Section of the ACS
  • 2010 – Present
    Faculty Advisor for the Sailing Club at UWM
  • List of Publications
  • Awards
    1. 2014 Outreach Volunteer of the Year for the Milwaukee ACS Section
    2. 2023 UWM Academic Staff Outstanding Performance & Service Award

Publications

In Preparation
Submitted
Accepted
  1. Maria Shteynbuk, Sharif A. Asad, Frank Holger Försterling and M. Mahmun Hossain; “Mechanistic Studies of Asymmetric α-Chlorination of Hydroxyacrylate”, Helvetica Chimica Acta
Published
  1. Smith, Charles D.; Foersterling, F. Holger; Dietz, Mark L., “Solvent structural effects on the solubility of bis(2-ethylhexyl)phosphoric acid (HDEHP) in room-temperature ionic liquids”, SEPARATION SCIENCE AND TECHNOLOGY, 2021,56(4), 800-810.
  2. M. Shahid Islam, Syarhabil Ahmad, Mary Rose Attu, F. Holger Foerstering and M. Mahmun Hossain* “Concise Synthesis of 2-Arylpropanoic Acids and Study of Unprecedented Reduction of 3-Hydroxy-2-arylpropenoic Acid Ethyl Ester to 2-Arylpropenoic Acid Ethyl Ester by BH3˙THF” Helvetica Chimica Acta 2015, 98(9) 1273-1286.
  3. Brett A. Beaupre, Matt Hoag, Joseph Roman, F. Holger Försterling, Graham Moran; “A Metabolic Function for Renalase: Oxidation of Isomeric Forms of β-NAD(P)H that Inhibit Primary Metabolism.” Biochemistry 2015 54(3) 795-806.
  4. Uddin Nazim; Ulicki Joseph S.; Foersterling F. Holger; “Bronsted acid-catalyzed C-C bond forming reaction for one step synthesis of oxazinanones” Tetrahedron Letters 2011 52(33), 4353-4356.
  5. Kumpaty, Hephzibah J, Van Linn, Michael L., Kabir, M. Shahjahan, Foersterling, F. Holger, Deschamps, Jeffrey R., Cook, James A.; “Study of the Cis to Trans Isomerization of 1-Phenyl-2,3-disubstituted Tetrahydro-beta-carbolines at C(1). Evidence for the Carbocation-Mediated Mechanism”; Journal of Organic Chemistry 2009 74 (7), 2771-2779.
  6. Han, D.; Försterling, F. H.; Li, X.; Deschamps, J.; Cao, H. and Cook, J. M.; “A study of the structure-activity relationship of GABA(A)-benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis ” Bioorganinc and Medicinal Chemistry 2008 16(190 8853-8862.
  7. Islam,S.,Ahmad, Syarhabil;Försterling, F.H.; Hossain, M.M; ” First unambiguous characterization of a novel RO-BH2 intermediate by H-1{B-11} and H-1{C-13,B-11} NMR spectroscopy. Proof of boron-carbonyl interaction through innovative use of NMR techniques” Organometallics 2008,27 (10) 2354-2355.
  8. Han, D; Försterling, Deschamps, J. R.; Parrish, D.; Liu, X.; Cook, J. M.; ” Conformational analysis of the cis- and trans-adducts of the Pictet-Spengler reaction. Evidence for the structural basis for the C(1)-N(2) scission process in the cis- to trans-isomerization” J. Natural Products 2007 70 (1) 75-82
  9. Casper, D. J.; Sklyarov, A. V.; Barr, T. L.; Försterling, F. H.; Surerus, K. F.; Hossain, M. M.; “Bonding mechanism of an iron Lewis acid-THF adduct on silica gel.” Inorganica Chimica Acta2006 359 (10) 3129-3138
  10. Ahmed MG, Ahmed SA, Akhter K, Tsuda Y, Hossain MM, Forsterling FH; “Synthesis of substituted tricyclo[5.3.1.0(4,9)]undecan-2,6-dione from 4,4-disubstituted cyclohexanone enamines and methacryloyl chloride” Synthetic Communications 200636 (9) 1273-1283
  11. Wang, Q.; Försterling, F. H.; Hossain, M. M.; “Study of the Origin of Enantioselectivity in Cyclopropanation Reactions using the Chiral Ion Carbene Complex [(η5-C 5H5)(CO)2Fe=CH [(η 6 –o-MeOC6H4)Cr(CO)3]] +.” Journal of Organometallic Chemistry 2005,690,6238-6246.
  12. Ahmed MG, Ahmed SA, Akhter K, Moeiz SMI, Tsuda Y, Kiuchi F, Hossain MM, Forsterling FH; “Synthesis of some substituted adamantane-2,4-diones from 4, 4-disubstituted cyclohexanone enamines and methacryloyl chloride.” Journal of Chemical Research-S 2005,(5), 293-298
  13. Krepkiy, D; Försterling, F. H.; Petering, D. H.; “Effect of Cd2+ on Transcription Factor IIIA: Zn- and Cd-Finger 3 Structure and Interaction with Cognate DNA.” Chemical Research in Toxicology2004, 17(7) 863-870
  14. Han, D. M.; Försterling, F. H.; Cook, J.; “Study on the Conformational Structure-Activity Relationship of GABAA-Benzodiazepine Receptor Bivalant Ligands by Low Temperature NMR”.Bioorganic & Medicinal Chemistry Letters 2004,14(6) 1465-1469
  15. Xia, C.; Försterling, F. H.; Petering, D. H.; “The Internal Axial Ligand of Hydroperoxy -Co(III)-Bleomycin: 1H-15N HSQC NMR investigation of Bleomycin, Deglycobleomycin , and their Hydroperoxy-Co(III) Complexes.” Biochemistry2003,42(21) 6559-6564.
  16. Sieber, F.; Daziano, J. P.; Anderson, G.S.; Miyagi, K.; Sampson, R.W.; Tsujino, L.; Gunther, W. H.; Krieg, M.; Bousbaa, J.; Försterling, F. H.; “Colloidal selenium generated by photobleaching of selenomerocyanine dyes combines with serum macromolecules to form conjugates that are preferentially cytotoxic to leukemia and selected solid tumor cells.” Blood 2002, 100 (11), 4411.
  17. Muñoz, A.; Försterling, F. H.; Shaw, C. F. III; Petering, D; “Structure of the 113Cd3 β domains of Homarus americanus Metallothionein-1: Hydrogen bonding and Solvent Accesibility of Sulfur Atoms .” Journal of Biological Inorganic Chemistry 2002,7(7-8), 713-724.
  18. Zhao, C.; Xia, C.; Mao, Q.; Försterling, F. H.; DeRose, E.; Antholine, W.E.; Subczynski, W.K.; Petering, D.H.; “Structures of HO(2)-Co(III)bleomycin A(2) bound to d(GAGCTC)(2) and d(GGAAGCTTCC)(2): structure-reactivity relationships of Co and Fe bleomycins.” J Inorg Biochem 2002, 91(1), 259-268.
  19. Wang, Q.; Islam, S. M.; Försterling, F. H.; Hossain, M. M.; “Enantiospecific Cyclopropane Synthesis Using the Chiral Iron Carbene Complexes S- and R-[(η 5-C5 H5)(CO)2Fe=CH [(η 6 –o-CH3C6H4)Cr(CO) 3 ]] +.”  Organometallics 2002,21(13), 2596-2598.
  20. Ejnik, J.; Robinson, J.; Zhu, J.; Försterling, F. H.; Shaw III, C. F.; Petering, D. H.; “Folding pathway of apo-metallothionein induced by Zn2+, Cd2+ and Co2+.” J Inorg Biochem 2002 88(2),144-52
  21. Lemos, Sebastião S.; Camargo, M. A.; Cardoso, Z. Z.; Deflon, V. M.; Försterling, F. Holger; Hagenbach, A.; “Copper(I) Pseudohalide Complexes with 4,6-Dimethylpyrimidine and Triphenylphosphane as Ligands. The X-ray structure of [Cu(N3(dmpymtH)(PPh3) 2 ] and [Cu(NCS(dmpymtH)(PPh3)2]”, Polyhedron 2001, 20(9-10) , 849-854.
  22. Försterling, F. H.; Barnes, C. E.; “Methylidene and hydrazone complexes of the cluster family: Cp’3M3(CO)2 (CH2) (M=Co, Rh, Ir)”, Journal of Organometallic Chemistry 2001, 617, 561-570.
  23. Elshorst, B.; Hennig, M.; Försterling, F. H.; Diener, A.; Maurer, M.; Schulte, P.; Schwalbe, H.; Krebs, J.; Schmid, H; Vorherr, T.; Carafoli, E.; Griesinger, C.; “NMR Solution Structure of a Complex of Calmodulin with a Binding Peptide of the Ca2+-Pump”, Biochemistry 1999, 38, 12320-12332.
  24. Barnes, C. E.; Försterling, F. H. ; “Alkylidene dynamics in the cluster complex Cp*Rh(CpCo)2( μ2-CO)2 ( μ 2 -CH2): Observation of an intermediate containing a μ3-methylidene ligand”, Polyhedron 1998, 17 (7), 1045-1054.
  25. Försterling, F. H.; Barnes, C. E., King, W. D.; “Diffusional and Internal Rotation in Single and Linked Trinuclear Bis-Carbyne Cluster Complexes Determined by 13C NMR Relaxation Time Measurements”, Inorg. Chemistry 1997, 36, 3532-3538.
  26. Försterling, F. H., Barnes, Craig E.; “Carbene Migration in a Cluster Complex. Observation of a µ3-CH2 Ligand”, J. Am. Chem. Soc.1997, 119 , 7585 -7586.
  27. Geiger, W. E.; Shaw, M. J.; Wünsch, M.; Barnes, C. E.; Försterling, F. H.; “Comparison of Isomerization Rates of the Metal Carbonyl Cluster Cp*IrCp2Co2(CO)3 in Three Oxidation States (47e, 48e, 49e): Dramatic Rate Enhancements in the Odd-Electron Species”; J. Am. Chem. Soc. 1997, 119 , 2804-2811.
  28. Försterling, F. H.; Barnes, C. E.; “Reversible Carbene-Carbyne Interconversion on a Trinuclear Cobalt Cluster”; Organometallic 1994, 13, 3770-3772.
  29. Geletneky, C.; Försterling, F. H.; Bock, W.; Berger, S.; “A Dynamic Equilibrium of Oxaphosphetanes”; Chem. Ber. 1993 , 126, 2397-2401.

Book Reviews

  1. “Spin dynamics: Basics of Nuclear Magnetic Resonance, Second Edition”. Malcolm H. Levitt, Author and Frank Holger Försterling, Reviewer Medical Physics2010 37(1), 406-407.

Presentations:

    1. “Through bond correlations of I > 1/2 nuclei: One and two dimensional 1H{11B} NMR spectroscopy applied to the elucidation of the mechanism of an unusual hydroboration reaction”
      46th Experimental Nuclear Resonance Conference Providence, RI, April 2005 (Poster)
    2. “The Internal Axial Ligand of Hydroperoxy-Co(III)-Bleomycin: 1H-15N HSQC NMR investigation of Bleomycin, Deglycobleomycin , and their Hydroperoxy-Co(III) Complexes.”;
      44th Experimental Nuclear Resonance Conference Savannah, GA, April 2003 (Poster)
    3. “NMR Studies of 113Cd3-β Domains of Lobster Metallothionein: Structure and Hydrogen Bonding”;
      Midwest Bruker User Meeting 2001 Medical College, Milwaukee WI October 2001 (invited talk)
    4. “Lobster Metallothionein 113 Cd3-β Domain Solvent Atom Exposure Patterns Studied by NMR Spectroscopy:
      Impact on Metal-Thiolate Cluster Reactivity”;
      42ndExperimental Nuclear Resonance Conference Orlando, FL, March 2001(Poster)
    5. “Determination of the three dimensional Structure and HN–S Hydrogen Bonding of the synthetic 113Cd 3-βN Domain of Lobster MT-1 by NMR spectroscopy”;
      41st Experimental Nuclear Resonance Conference Pacific Grove CA, March 2000 (Poster)
    6. “Determination of the Solution Three Dimensional Structure of Chemically-Synthesized Native Cd3βC Domain of Lobster Metallothionein by NMR Spectroscopy.”
      41st Experimental Nuclear Resonance Conference Pacific Grove CA, March 2000 (Poster)
    7. “Structure Determination and Dynamics of Calmodulin in Complex with C20W and C21W, Cognate Peptides of the Plasma Membrane Calcium Pump”;
      40th Experimental Nuclear Resonance Conference Orlando FL, March 1999 (Poster).
    8. “Structure Determination of Calmodulin in Complex with C20W and C21W, Cognate Peptides of the Plasma Membrane Calcium Pump”; 39th Experimental Nuclear Resonance Conference Pacific Grove CA, March 1998 (Poster).
    9. “Structure Determination of Calmodulin in Complex with C20W and C21W, Cognate Peptides of the Plasma Membrae Calcium Pump”; Diskussionstagung der Gesellschaft Deutscher Chemiker Fachgruppe Magnetische Resonanzspektroskopie Friedrichsroda, Germany, September 1997 (Poster).
    10. “Carbene Migration in a Cluster Complex: Observation of an Intermediate Containing a µ3-CH2 Ligand Investigated by Two-Dimensional 1H{13C} and 1H{ 103Rh} NMR Spectroscopy”; 213th American Chemical Society National Meeting< San Francisco CA; April 1997 (oral).
    11. “1H, 13C and 103Rh Triple Resonance Studies to Characterize a Cluster Complex Containing a Triply Bridging Carbene Ligand”, 17th Experimental Nuclear Magnetic Resonance Conference Orlando FL, March 1997.
    12. “Carbene Mobility in Trinuclear Mixed Metal Cluster Complexes: Presence of a Terminal Carbene ?”, 211th American Chemical Society National Meeting New Orleans LA; March 1996 (oral).
    13. “Diffusional and Internal Rotation in Single and Linked Bis-Carbyne Clusters Determined by Carbon-13 Relaxation Times”, 210th American Chemical Society National Meeting Chicago IL; August 1995 (poster).
    14. “Alkyne Adducts of Mixed Metal Trinuclear Clusters of the Cobalt Group : Synthesis and Fluxional Behavior”, 210th American Chemical Society National Meeting Chicago IL; August 1995 (oral).
    15. “Carbene Chemistry of Trinuclear Clusters of the Cobalt Group”, 46th American Chemical Society Southeastern Regional Meeting Birmingham AL, October 1994 (oral).
    16. “Carbene Chemistry of Trinuclear Clusters of the Cobalt Group”, 208th American Chemical Society National Meeting Washington DC, August 1994 (oral).
    17. “Carbene and Carbyne Ligands on Trinuclear Clusters of the Cobalt Group”, 45th American Chemical Society Southeastern Regional Meeting Johnson City TN, October 1993 (oral).
    18. “Investigation of the Wittig Reaction using Rapid Injection NMR Spectroscopy”, 13. Diskussionstagung der Gesellschaft Deutscher Chemiker Fachgruppe Magnetische Resonanzspektroskopie Todtmoos, Germany, October 1991 (poster).

On line poster presented by NMR facility staff

  • Structure Determination and Dynamics of Calmodulin in Complex with C20W and C21W,Cognate Peptides of the Plasma Membrane Calcium Pump
    by B. Elshorst, F. H. Försterling, M. Hennig, A. Diener, M. Maurer, P. Schulte, H. Schwalbe, C. Griesinger, J. Krebs, H. Schmidt, T. Vorherr, E. Carafoli
    A poster presented at the 40st ENC in Orlando 1999.
  • Determination of the three dimensional Structure and HN–S Hydrogen Bonding of the synthetic 113Cd3–bN Domain of Lobster MT-1 by NMR spectroscopy
    by Amalia Muñoz, F. Holger Försterling, C. Frank Shaw III and David Petering
    A poster presented at the 41st ENC at Asilomar, CA.
  • Determination of the Solution Three Dimensional Structure of Chemically- Synthesized Native Cd3bC Domain of Lobster Metallothionein by NMR Spectroscopy.
    by Amalia Muñoz, F. Holger Försterling, C. Frank Shaw III and David Petering
    A poster presented at the 41st ENC at Asilomar,CA.
  • Lobster Metallothionein 113Cd3–b Domain Solvent Atom Exposure Patterns Studied by NMR Spectroscopy:
    Impact on Metal-Thiolate Cluster Reactivity
    by by Amalia Muñoz, F. Holger Försterling, C. Frank Shaw III and David Petering
    A Poster presented at the 42nd ENC in Orlando, FL
  • The Internal Axial Ligand of Hydroperoxy-Co(III)-Bleomycin: 1H-15N HSQC NMR investigation of Bleomycin, Deglycobleomycin, and their Hydroperoxy-Co(III) Complexes.
    by Chuanwu Xia; Chunching Zhao;F. Holger Försterling, and David Petering
    A Poster presented at the 44th ENC in Savannah, GA