Upcoming publication: Our accepted manuscript is an Advance Article in GENETICS
Townley RA, Stacy KS, Cheraghi F, de la Cova CC. The Raf/LIN-45 C-terminal distal tail segment negatively regulates signaling in Caenorhabditis elegans. Advance Article. https://academic.oup.com/genetics/advance-article/doi/10.1093/genetics/iyae152/7759357
Publications on development and MAP kinase signaling in the worm:
Rodriguez Torres CS, Wicker NB, Puccini de Castro V, Stefinko M, Bennett DC, Bernhardt B, Garcia Montes de Oca M, Jallow S, Flitcroft K, Palalay JS, Payán Parra OA, Stern YE, Koelle MR, Voisine C, Woods IG, Lo T, Stern MJ, de la Cova CC. The Caenorhabditis elegans protein SOC-3 permits an alternative mode of signal transduction by the EGL-15 FGF receptor. Developmental Biology. Dec 2024. Epub ahead of print. doi.org/10.1016/j.ydbio.2024.08.014.
Townley R, Deniaud A, Stacy KS, Rodriguez Torres CS, Cheraghi F, Wicker NB, de la Cova CC. The E3/E4 ubiquitin ligase UFD-2 suppresses normal and oncogenic signaling mediated by a Raf ortholog in Caenorhabditis elegans. Sci Signal. 2023 Aug 29;16(800):eabq4355. doi: 10.1126/scisignal.abq4355.
de la Cova CC, Townley R, Greenwald I. Negative feedback by conserved kinases patterns the degradation of Caenorhabditis elegans Raf in vulval fate patterning. Development. 2020 Dec 23;147(24):dev195941. doi: 10.1242/dev.195941.
de la Cova C, Townley R, Regot S, Greenwald I. A Real-Time Biosensor for ERK Activity Reveals Signaling Dynamics during C. elegans Cell Fate Specification. Dev Cell. 2017 Sep 11;42(5):542-553.e4. doi: 10.1016/j.devcel.2017.07.014.
de la Cova C, Greenwald I. SEL-10/Fbw7-dependent negative feedback regulation of LIN-45/Braf signaling in C. elegans via a conserved phosphodegron. Genes Dev. 2012 Nov 15;26(22):2524-35. doi: 10.1101/gad.203703.112.
Publications on cell competition in the fruit fly:
Kodra AL, Sharma Singh A, de la Cova C, Ziosi M, Johnston LA. The Drosophila TNF Eiger promotes Myc super-competition independent of canonical JNK signaling. Genetics. 2024 Jul 10:iyae107. doi: 10.1093/genetics/iyae107.
Kodra A, de la Cova C, Gerhold AR, Johnston LA. Widely Used Mutants of eiger, Encoding the Drosophila Tumor Necrosis Factor, Carry Additional Mutations in the NimrodC1 Phagocytosis Receptor. G3 (Bethesda). 2020 Dec 3;10(12):4707-4712. doi: 10.1534/g3.120.401800.
Meyer SN, Amoyel M, Bergantiños C, de la Cova C, Schertel C, Basler K, Johnston LA. An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science. 2014 Dec 5;346(6214):1258236. doi: 10.1126/science.1258236.
de la Cova C, Senoo-Matsuda N, Ziosi M, Wu DC, Bellosta P, Quinzii CM, Johnston LA. Supercompetitor status of Drosophila Myc cells requires p53 as a fitness sensor to reprogram metabolism and promote viability. Cell Metab. 2014 Mar 4;19(3):470-83. doi: 10.1016/j.cmet.2014.01.012.
de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA. Drosophila myc regulates organ size by inducing cell competition. Cell. 2004 Apr 2;117(1):107-16. doi: 10.1016/s0092-8674(04)00214-4.