Microfabrication of LOC Device Utilizing Micro Pump and Micro Valve Flow Mechanisms

Manav Menon, “Microfabrication of LOC Device Utilizing Micro Pump and Micro Valve Flow Mechanisms”
Mentors: Marcia Silva and Alice Lecus, Global Water Center

Over the last decade microfabrication techniques have been implemented for the fabrication of Lab-on-a-chip (LOC) systems. These systems can conduct various types of chemical and cellular analysis, facilitating fluid transport, mixing, or separation of liquid samples. The LOC systems incorporate microarray and microfluidics to assemble a micro total analytic system. The miniaturization of analytical systems that integrate microfluidic LOCs and numerous sensory devices are significant to automate laboratory procedures. This will allow a reduction of the time elapsed to conduct chemical and biological tests, reducing manufacturing costs and increasing production capabilities. The study will focus on the development and fabrication of a LOC system that contains micro-pump and microvalve devices to precisely actuate a series of reagents, which will selectively pressurize the polydimethylsiloxane (PDMS) channels to actuate multiple reagents in a controlled manner. The PDMS will be pressurized by a roller bar that is operated by a programmable microprocessor. These sub-cellular biomaterial micropatterns can effectively be employed to study various engineering applications.

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