Ireoluwa Adams, “In-Vitro Proteomics Analysis of Gallium Maltolate-Treated Glioblastoma Xenograft Rat”
Mentor: Mirza Shama, Chemistry & Biochemistry, Letters & Science (College of)
Poster #65
Glioblastoma, the most aggressive form of glioma (Stage IV), carries a grim prognosis, with a survival span of less than 15 months post-diagnosis. The limited effectiveness of current pharmaceutical and surgical interventions underscores the urgent need for early diagnostic and prognostic biomarkers to improve patient outcomes. Disease-associated proteins hold significant clinical value as biomarkers, serving as indicators of biological processes and pathological states while also guiding drug discovery by identifying potential therapeutic targets. In this study, we utilize molecular biology techniques and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze differentially expressed proteins in plasma samples from glioblastoma xenograft rat treated with gallium maltolate. This approach aims to enhance our understanding of patient responses to the drug and to identify potential therapeutic partners that could lead to new treatment options for combating the disease.