Se Jin Lee, “Polyacrylamide (Pam) and Aloe Vera Hydrogel: A Novel Approach for Accelerated Burn Wound Healing”
Mentor: Qingsu Cheng, Biomedical Engineering
Poster #52

Burn wounds are a significant challenge in medical treatment, necessitating innovative solutions to address the pain, debilitation, and emotional distress they cause. Immediate and appropriate first aid, followed by ongoing medical attention, is crucial for managing burns effectively. Hydrogel dressings have emerged as a common and effective treatment option for burn wounds, offering a moist environment conducive to healing. However, to further enhance their therapeutic potential, we have introduced a novel bioactive hydrogel formulation combining the healing properties of aloe vera with the mechanical strength of polyacrylamide (PAM). Aloe vera has long been recognized for its medicinal properties, particularly in treating burns. Its cooling and soothing effects, along with its anti-inflammatory and antimicrobial properties, make it a popular natural remedy. In contrast, polyacrylamide provides mechanical support to hydrogel, contributing to its stability and durability. The integration of these two components into a single hydrogel formulation presents a promising advancement in burn wound care. The synthesis process involves mixing aloe vera extract with polyacrylamide at an elevated temperature of 60 degrees Celsius. This temperature facilitates the incorporation of aloe vera into the hydrogel matrix while ensuring proper dispersion of polyacrylamide. Cross-linking of the hydrogel is achieved through Schiff Base Reactions, resulting in a stable and bioactive material suitable for clinical applications. By harnessing the healing properties of aloe vera in combination with the mechanical strength of polyacrylamide, the proposed hydrogel offers a multifaceted approach to burn wound management. It not only provides a supportive environment for wound healing but also exhibits enhanced durability under clinical conditions. This bioactive hydrogel holds great promise in advancing the field of burn care, offering a novel therapeutic option for healthcare professionals and patients alike. Further research and clinical trials are warranted to validate its efficacy and safety in real-world settings.