A Coupling Reaction between a Benzophenone and Racemic BOC Alanine

Arnold, Alexander, Chemistry & Biochemistry, College of Letters & Science, Mentor, Poster Presentation, School and College, Student, Wheeler, Grace

Grace Wheeler “A Coupling Reaction between a Benzophenone and Racemic BOC Alanine ”
Mentor: Alexander Arnold, Chemistry & Biochemistry
Poster #13

The reactions that have been performed include a coupling reaction between a benzophenone and racemic alanine , where the product would be used in further reactions to yield novel pegylated GABA(A) receptor ligands. The compound purification method is trituration, and for the characterization, nuclear magnetic resonance spectrometry was used. In the future, we are planning to determine the solubility and permeability to identify compounds with preferable properties for drug development. The intention is the synthesis of novel pegylated GABA(A) receptor ligands that will be evaluated as novel treatments for asthma.