About RIIO

Major advances in fluorescence-based molecular-imaging technologies, such as FRET and fluorescence fluctuation spectroscopies, and molecular dynamics simulations have spurred the development of exquisite methods for reliably probing protein association in silico, in vitro, and in vivo. The Receptor Interactions and Intracellular Organization Alliance (RIIO Alliance) focuses on the relationship between quaternary structure and function of cellular receptors under various environmental conditions, e.g., expression levels, the presence of ligand or other binding partners, and membrane composition and structure. As our techniques are standardized and cross-validated, our initial focus on two large families of membrane receptors — GPCRs and Tyrosine Kinases — will eventually expand to include any receptor with a well-characterized gene and amino acid sequence.