2018

De La Rosa, I.J., Azimipour, M., Cullen, P.K., Helmstetter, F.J., Pashaie R. (2018). Angularly Resolved Deep Brain Fluorescence Imaging Using a Single Optical Fiber. International Journal of Optics.

Belleau, E.L., Pedersen, W.S., Miskovich, T.A., Helmstetter, F.J., Larson, C.L. (2018). Cortico-limbic connectivity changes following fear extinction and relationships with trait anxiety. Social cognitive and affective neuroscience, 13 (10), 1037-1046.


2017

Jarome, T.J., Helmstetter, F.J. (2017). Ubitquitin Proteasome System, Protein Degradation, and Memory. In: Sara, S.J. (ed.), Mechanisms of Memory, Vol. 4
of Learning and Memory: A Comprehensive Reference, 2nd edition, Byrne, J.H. (ed.). pp. 279–291. Oxford: Academic Press.

Cullen, P.K., Ferrara, N.C., Pullins, S.E., Helmstetter, F.J. (2017). Context memory formation requires activity dependent protein degradation in the hippocampus. Learning and Memory, 24, 589-596. View PDF »

Kwapis, J.L., Jarome, T.J., Ferrara, N.C., & Helmstetter, F.J. (2017). Updating procedures can reorganize the neural circuit supporting a fear memory. Neuropsychopharmacology, 42, 1688-1697. View PDF »

Ferrara, N.C., Cullen, P.K., Pullins, S.E., Rotondo, E.K., Helmstetter, F.J. (2017). Input from the medial geniculate nucleus modulates amygdala encoding of fear memory discrimination. Learning and Memory, 24, 414-421.  View PDF »


2016

Hannula, D.E., Helmstetter, F.J. (2016). Hippocampal interactions with brain networks that influence learning & memory. Neurobiology of Learning and Memory, 134, Pt A: 1-4. View PDF »

Hopkins, L.S., Helmstetter, F.J., Hannula, D.E. (2016). Eye Movements are Captured by a Perceptually Simple Conditioned Stimulus in the Absence of Explicit Contingency KnowledgeEmotion, EPub. View PDF »

Schultz, D.H., Balderston, N.L., Baskin-Sommers, A.R., Larson, C.L., Helmstetter, F.J. (2016).  Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning. Frontiers in Psychology, 7, 348, 1-12. View PDF »

Jarome, T.J., Ferrara, N.C., Kwapis, J.L., Helmstetter, F.J. (2016). CaMKII regulates proteasome phosphorylation and activity and promotes memory destabilization following retrieval. Neurobiology of Learning and Memory, 128, 103-109. View PDF »


2015

Hopkins, L.S., Schultz, D.S., Hannula, D.E., Helmstetter, F.J. (2015). Eye Movements Index Implicit Memory Expression in Fear Conditioning. PLoS ONE, 10(11), 1-19. View PDF »

Kwapis, J.L., Jarome, T.J., Lee, J.L., Helmstetter, F.J. (2015). The retrosplenial cortex is involved in the formation of memory for context and trace fear conditioning. Neurobiology of Learning and Memory, 123, 110-116. View PDF »

Jarome, T.J., Ferrara, N.C., Kwapis, J.L., Helmstetter, F.J. (2015). Contextual Information Drives the Reconsolidation-Dependent Updating of Retrieved Fear memories. Neuropsychopharmacology, 40(13),3044-3052. View PDF »

Balderston, N.L., Schultz, D.S., Hopkins, L.S., Helmstetter, F.J. (2015). Functionally distinct amygdala subregions identified using DTI and high-resolution fMRI. Social Cognitive and Affective Neuroscience, 10(12), 1615-1622. View PDF »

Kwapis, J.L., Jarome, T.J., Helmstetter, F.J. (2015). The role of the medial prefrontal cortex in trace fear extinction. Learning and Memory, 22(1), 39-46. View PDF »


2014

Balderston, N.L., Schultz, D.H., Baillet, S., Helmstetter, F.J. (2014). Rapid amygdala responses during trace fear conditioning without awareness. PLOS ONE, 9(5). e96803. View PDF »

Gilmartin, M.R., Balderston, N.L., Helmstetter, F.J. (2014). Prefrontal cortical regulation of fear learning. Trends in Neuroscience, 37(8), 455-464. View PDF »

Jarome, T.J., Kwapis, J.L., Hallengren, J.J., Wilson, S.M., Helmstetter, F.J. (2014). The ubiquitin-specific protease 14 (USP14) is a critical regulator of long-term memory formation. Learning and Memory, 21, 748-751. View PDF »

Jarome, T.J., Helmstetter, F.J. (2014). Protein degradation and protein synthesis in long-term memory formation. Frontiers in Molecular Neuroscience, 7:61. View PDF »

Kwapis, J.L., Helmstetter, F.J. (2014). Does PKM(zeta) maintain memory? Brain Research Bulletin, 105, 36-45. View PDF »

Kwapis, J.L., Jarome, T.J., Lee, J.L., Gilmartin, M.G., Helmstetter, F.J. (2014). Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala. Neurobiology of Learning and Memory, 113, 41-54. View PDF »


2013

Kwapis, J.L., Jarome, T.J., Lee, J.L., Gilmartin, M.G., Helmstetter, F.J. (2013). Extinguishing trace fear engages the retrosplenial cortex rather than the amygdala. Neurobiology of Learning and Memory, 113, 41-54. View PDF »

Reis, D.S., Jarome, T.J., Helmstetter, F.J. (2013). Memory formation for trace fear conditioning requires ubiquitin-proteasome mediated protein degradation in the prefrontal cortex. Frontiers in Behavioral Neuroscience 7:150, 107-116. View PDF »

Jarome, T.J., Helmstetter, F.J. (2013). The ubiquitin-proteasome system as a critical regulator of synaptic plasticity and long-term memory formation. Neurobiology of Learning and Memory 105, 107-116. View PDF »

Jarome, T.J., Kwapis, J.L., Ruenzel, W.L., Helmstetter, F.J. (2013). CamKII, but not protein kinase A, regulates Rpt6 phosphorylation and proteasome activity during the formation of long-term memories. Frontiers in Behavioral Neuroscience 7:115. View PDF »

Gilmartin, M.R., Miyawaki, H., Helmstetter, F.J., Diba, K. (2013). Prefrontal activity links nonoverlapping events in memory. Journal of Neuroscience 33(26), 10910-10914. View PDF »

Balderston, N.L., Schultz, D.H., Baillet, S., Helmstetter, F.J. (2013). How to detect amygdala activity with magnetoencephalography using source imaging. Journal of Visulaized Experiments 3(76). View PDF » View video »

Schultz, D.H., Balderston, N.L., Geiger, J.A., Helmstetter, F.J. (2013). Dissociation between implicit and explicit responses in postconditioning UCS revaluation after fear conditioning in humans. Behavioral Neuroscience 127(3), 357-368. View PDF »

Gilmartin, M.R., Kwapis, J.L., Helmstetter, F.J. (2013). NR2A- and NR2B-containing NMDA receptors in the prelimbic medial prefrontal cortex differentially mediate trace, delay, and contextual fear conditioning. Learning and Memory 20(6), 290-294. View PDF »

Balderston, N.L., Schultz, D.H., Helmstetter, F.J. (2013). The effect of threat on novelty evoked amygdala responses. PLoS One 8(5). View PDF »

Gafford, G.M., Parsons, R.G., Helmstetter, F.J. (2013). Memory accuracy predicts hippocampal mTOR pathway activation following retrieval of contextual fear memory. Hippocampus 23(9), 842-847. View PDF »


2012

Schultz, D.H., Balderston, N.L., Helmstetter, F.J. (2012). Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning.
Frontiers in Human Neuroscience. View PDF »

Gilmartin, M.R., Kwapis, J.L., Helmstetter, F.J. (2012). Trace and contextual fear conditioning are impaired following unilateral microinjection of muscimol in the ventral hippocampus or amygdala, but not the medial prefrontal cortex. Neurobiology of Learning & Memory 97,300-306. View PDF »

Jarome, T.J., Kwapis, J.L., Werner, C.T., Parsons, R.G., Gafford, G.M., Helmstetter, F.J. (2012). The timing of multiple retrieval events can alter GluR1 phosphorylation and the requirement for protein synthesis in fear memory reconsolidation. Learning & Memory 19, 452-464. View PDF »

Kwapis, J.L., Jarome, T.J., Gilmartin, M.R., Helmstetter, F.J. (2012). Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts context fear memory. Neurobiology of Learning & Memory 98,148-153. View PDF »


2011

Kwapis, J.L., Jarome, T.J., Schiff, J.C., Helmstetter, F.J. (2011). Memory consolidation in both trace and delay fear conditioning is disrupted by intra-amygdala infusion of the protein synthesis inhibitor anisomycin. Learning & Memory 18, 728-732. View PDF »

Jarome, T.J., Werner, C.T., Kwapis, J.L., Helmstetter, F.J. (2012). Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. PLoS ONE 16(9), e24349. View PDF »

Gafford, G.M., Parsons, R.G., Helmstetter, F.J. (2012). Consolidation and reconsolidation of contextual fear memory requires mammalian target of rapamycin-dependent translation in the dorsal hippocampus. Neuroscience 182, 98-104. View PDF »

Balderston, N.L., Schultz, D.H., Helmstetter, F.J. (2012). The human amygdala plays a stimulus specific role in the detection of novelty. Neuroimage 55(4), 1889-1898. View PDF »


2010

Schultz, D.H., Helmstetter, F.J. (2010). Classical conditioning of autonomic fear responses is independent of contingency awareness. Journal of Experimental Psychology: Animal Behavior Processes 36(4), 495-500. View PDF »

Balderston, N.L., Helmstetter, F.J. (2010). Conditioning with masked stimuli affects the timecourse of skin conductance responses. Behavioral Neuroscience 124(4), 478-489. View PDF »

Gilmartin, M.R., Helmstetter, F.J. (2010). Trace and contextual fear conditioning require neural activity and NMDA receptor-dependent transmission in the medial prefrontal cortex. Learning & Memory 17, 289-296. View PDF »

Jarome, T.J., Kwapis, J.L., Nye, S., Helmstetter, F.J. (2010). Introgression of Brown Norway Chromosome 1 onto the Fawn Hooded Hypertensive Background Rescues Long-Term Fear Memory Deficits. Behavior Genetics 40(1), 85-92. View PDF »

Lonergan, M.E., Gafford, G.M., Jarome, T.J., Helmstetter, F.J. (2010). Time-dependent expression of Arc and zif268 after acquisition of fear conditioning. Neural Plasticity. View PDF »

Parsons, R., Gafford, G.M., Helmstetter, F.J. (2010). Regulation of extinction-related plasticity by opioid receptors in the ventrolateral periaqueductal gray matter. Frontiers in Behavioral Neuroscience 4. View PDF »


2009

Lee, T., Jarome, T.J., Li, S.J., Kim, J.J., Helmstetter, F.J. (2009). Chronic stress selectively reduces hippocampal volume in rats: a longitudinal magnetic resonance imaging study. Neuroreport 20(17), 1554-1558. View PDF »

Kwapis, J.L., Jarome, T.J., Lonergan, M.E. & Helmstetter, F.J. (2009). Protein kinase Mzeta maintains fear memory in the amygdala but not in the hippocampus. Behavioral Neuroscience 123, 844-850. View PDF »


2008

Helmstetter, F.J., Parsons, R.G. Gafford, G.M. (2008). Macromolecular synthesis, distributed synaptic plasticity, and fear conditioning. Neurobiology of Learning and Memory 89, 324-337. View PDF »


2007

Cheng, D.T., Richards, J., Helmstetter, F.J. (2007). Activity in the human amygdala corresponds to early, rather than late period autonomic responses to a signal for shock. Learning & Memory 14(7), 485-490. View PDF »


2006

Parsons, R.G., Gafford, G.M., Helmstetter, F.J. (2006). Translational control via the mamilian target of rapamycin pathway is critical for the formation and stability of long term fear memory in amygdala neurons. Journal of Neuroscience 26(50), 12977-12983. View PDF »

Cheng, D.T., Knight, D.C., Smith, C.N., Helmstetter, F.J. (2006). Human amygdala activity during the expression of fear responses. Behavioral Neuroscience 120, 1187-1195. View PDF »

Parsons, R.G., Riedner, B.A., Gafford, G.M., Helmstetter, F.J. (2006). The formation of auditory fear memory requires the synthesis of protein and mRNA in the auditory thalamus. Neuroscience 141, 1163-1170. View PDF »

Parsons, R.G., Gafford, G.M., Baruch, D.E., Riedner, B.A., Helmstetter, F.J. (2006). Long term stability of fear memory depends on the synthesis of protein but not mRNA in the amygdala. European Journal of Neuroscience 23,1853-1859. View PDF »


2005

Shin, M.S., Helmstetter, F.J. (2005). Antinociception following application of DAMGO to the basolateral amygdala results from a direct interaction of DAMGO with mu opioid receptors in the amygdala. Brain Research. View PDF »

Gafford, G.M., Parsons, R.G. Helmstetter, F.J. (2005). Effects of post training hippocampal injections of midazolam on fear conditioning. Learning & Memory 12, 573-578. View PDF »


Earlier

Knight, D.C., Smith, C.N., Cheng, D.T., Stein, E.A., Helmstetter, F.J. (2004). Amygdala and huppocampal activity during acquisition and extinction of human fear conditioning. Cognitive, Affective, and Behavioral Neuroscience 4(3), 317-325.

Baruch, D.E., Swain, R.A., Helmstetter, F.J. (2004). Effects of exercise on Pavlovian fear conditioning. Behavioral Neuroscience Oct 118(5),1123-1127. View PDF »

Knight, D.C., Cheng, D.T., Smith, C.N., Stein, E.A., Helmstetter, F.J. (2004). Neural substrates mediating human delay and trace fear conditioning. Journal of Neuroscience 24(1), 218-228.

Cheng, D.T., Knight, D.C., Smith, C.N., Stein, E.A., Helmstetter, F.J. (2003). Functional MRI of human amygdala activity during Pavlovian fear conditioning: stimulus processing versus response expression. Behavioral Neuroscience 117(1), 3-10.

Bailey, D.J., Tetzlaff, J.E., Cook, J.M., He, X., Helmstetter, F.J. (2002). Effects of hippocampal injections of a novel ligand selective for the alpha 5 beta 2 gamma 2 subunits of the GABA/benzodiazepine receptor on Pavlovian conditioning. Neurobiology of Learning and Memory 78(1), 1-10.

Kocorowski, L.H., Helmstetter, F.J. (2001). Calcitonin gene-related peptide released within the amygdala is involved in Pavlovian auditory fear conditioning. Neurobiology of Learning and Memory 75(2), 149-163. 

Foo, H., Helmstetter, F.J. (2000). Activation of kappa opioid receptors in the rostral ventromedial medulla blocks stress-induced antinociception. Neuroreport 11(15), 3349-3352. View PDF »

Tershner, S.A., Helmstetter, F.J. (2000). Antinociception produced by mu opioid receptor activation in the amygdala is partly dependent on activation of mu opioid and neurotensin receptors in the ventral periaqueductal gray. Brain Research 865(1), 17-26. View PDF »

Foo, H., Helmstetter, F.J. (2000). Expression of antinociception in response to a signal for shock is blocked after selective downregulation of mu-opioid receptors in the rostral ventromedial medulla. Brain Research: Molecular Brain Research 76(2), 282-288. View PDF »

Knight, D.C., Smith. C.N., Stein, E.A., Helmstetter, F.J. (1999). Functional MRI of human Pavlovian fear conditioning: patterns of activation as a function of learning. Neuroreport 10(17), 3665-3670. View PDF »

Foo, H., Helmstetter, F.J. (1999). Hypoalgesia elicited by a conditioned stimulus is blocked by a mu, but not a delta or a kappa, opioid antagonist injected into the rostral ventromedial medulla. Pain 83(3), 427-431. View PDF »