Useful Resources for Organic Chemists

Tips & Tricks for Organic Chemists (Not Voodoo X) SynArchive: A total synthesis database Chem-Station Chemistry By Design  Total Syntheses by Reich at Madison pKa Tables (Bordwell, Evans) LC/MS Adducts and Clusters Organic Chemistry Portal ReactionFlash App by Reaxys (Android,… Read More

Recent Publications


443. “Antagonism of Triazolam Self-Administration in Rhesus Monkeys Responding Under a Progressive-ratio Schedule: In vivo Apparent pA2 Analysis,” Fischer, B; Platt, D.; Rallapalli, S.; Namjoshi, O.; Cook, J.; Rowlett, J.; Drug and Alcohol Dependence, 158, 22-29 (2016).
444. “eEF2 Pathway Controls Dentrate Gyrus Dependent Behaviour and Excitation-inhibition Balance,” Heise, C.; Taha, E.; Murru, L.; Ponzoni, L.; Cattaneo, A.; Guarnieri, F.C.; Montani, C.; Mossa, A.; Vezzoli, E.; Ippoliot, G.; Zapata, J.; Berrera, I.; Ryazanov, A.G.; Benfante, R.; Braida, D.; Francolinin, M.; Proud, Poe, M.M.; Stephen, M.; Cook, J.M.; C.; Valtorta, F.; Passafaro, M.; Sala, M.; Bachi, A.; Verpelli, C.; Rosenblum, K.; Sala, C.; Plus One, 00, 0000-0000 (2016).

445. “First in Vivo Testing of Novel Compounds Targeting Group 3 Medulloblastomas Using an Implantable Microdevice as a New Paradigm for Drug Development,” Jonas, O.; Calligaris, D.; Methuku, K.; Poe, M.M,; Tranghese, F.; Changelian, A.; Francois, J.; Sieghart, W.; Ernst, M.; Krummel, D.; Cook, J.M.; Pomeroy, S.; Cima, M.; Agar, N.; Langer, R.; Sengupta, S.; J. of Biomedical Nanotechnology, 12, 1297-1302 (2016).
446. “Modern Methods for the Total Synthesis of Important Oxindole Alkaloids.” Fonseca, G.; Cook, J.M.; Organic Chemistry Insights, 00, 0000-0000 (2016), in press.
447. “Sarpagine and Related Alkaloids,” O. Namjoshi; J.M. Cook, in “The Alkaloids,” Volume 76, Hans-Joachim Knölker, Editor, Elsevier, N.Y. pp. 64-171 (2016).
448. “Synthesis and Evaluation of Vitamin D Receptors-mediated Activities of Cholesterol and Vitamin D Metabolites,” Teske, K.; Bogart, J.; Sanchez, L.; Yu, O.; Preston, J.; Cook, J.; Silvaggi, N.; Bikle, D.; Arnold, L.; Eur. J. Med. Chem, 109, 238-246 (2016).
449. “Development of GABAA Receptor Subtype-Selective Imidazobenzodiazepines as Novel Asthma Treatments”, Forkuo, G.S.; Guthrie, M.; Yuan, N; Nieman, A.; Kodali, R; Jahan, R; Yocum, G.; Treven, M.; Stephen, M.; Poe, M.; Li, G.; Yu, O.; Hartzler, B.; Zahn, N.; Ernst, M.; Emala,C.; Stafford, D.; Cook, J.M.; Arnold, L.A., Molecular Pharmaceutics, (ACS), DOI: 10.1021/acs.molpharmaceut.6600159.
450. “ Identification of a Novel, Fast Acting GABAergic Antidepressent”, McMurray, K.; Ramakes, M.; Sidhu, P.; Elkin, P.; Cook, J.M.; Rawal, V.; Arnold,L.A.; Methuku, K.; Dulawa, S.;Palmer,A.; Nature Nerosci, submitted 0000-0000 (2016).
451. “Neonatal Bladder Inflammation Induces Long-term Visceral Pain and Altered Responses of Spinal Neurons in Adult Rats”, Kannampalli, P.; Babygirija,R.’ Zhang,J.; Poe,M.; Li,G.; Cook, J.M.; Shaker,R.; Banerjee, B.; Sengupta, J.; Submitted (2016).
452. “Modern Methods for Total Synthesis of Important Oxindole Alkaloids”, Fonseca, G.; Cook, J.M.; Organic Chemistry Insights 2016: 6 1-55 DOI: 10.4137/OCI.S17958.
453. “Early Life Stress is a Risk Factor for Excessive Alcohol Drinking and Impulsivity in Adults and is Mediated via a CRF/GABAA Mechanism”, Gondré-Lewis, M.C., Warnock, K.T., Wang, H., June Jr, H.L., Bell, K.A., Rabe, H., Tiruveedhula, V.V.N.P.B., Cook, J., Lüddens, H., Aurelian, L. and June Sr, H.L., 2016. Stress, 19(2), pp.235-247, DOI: 10.3109/10253890.2016.1160280.
454. “5-(8-Ethynyl-6-(Pyridin-2-yl)-4H-benzo[f] imidazo [1,5a] [,4] diazepine-3-yl) oxazole (KRM-II-81) is a Novel Alpha 2,3- Selective Potentiator of GABAA Receptors: Improved Bioavailability Enhances Anticonvulsent Effcacy”, Witkin, J.M.; Methuku, K.R.; McDermott,J.; Cerne,R.; Gleason,S.; Cramer,J.; Jones,T.M.; Catlow,J.; Poe,M.; Li,G.; Arnold,L.A.; Ping,X.; Jin,X.; Hobbs,J.; Smith,J.L.; Schkeryantz,J.; Cook, J.M.; J.Med.Chem, Submitted (2016).
455. “Synthesis and Characterzation of a Novel Anxiolytic GABAA Receptor Ligand that Combines Excellent Metabolic Stability, Pharmacokinetics and Anxiolytic Efficacy”, M.M.Poe; K. Methuku; J. Wikin; J. Schkeryantz; J. Cook et al., J. Med. Chem. Submitted.
456. “Total Synthesis of Macrocarpine D and E via an Enolate-Driven Copper-Mediated Cross-Coupling Process: Replacement of Catalytic Palladium with Copper Iodide”, Rahman, Md. T.; Deschamps, J.; Schwabacher, A.; Cook, J.M.; Org. Lett., 18 (17), pp 4174–4177 (2016). Link
457. “Synthesis of Bisindole Alkaloids from the Apocynaceae which Contain a
Macroline or Sarpagine Unit: A Review”, Rahman, Md. T.; Tiruveedhula, V. V. N. P. B.; Cook, J. M.; Special Issue “Diversity of Alkaloids”, Molecules 201621(11), 1525. Link


Benzodiazepine Ligands with Improved α5 Selectivity and Their Airway Smooth Muscle Relaxant Effect”, Puthenkalam, R.; Treven, M.; Ramerstorfer, J.; Steudle, F.; Scholze, P.; Gallos, G.; Poe, M.M.; Methuku, K.R.; Li, Guanguan; Arnold, L.A.; Seighert, W.; Santrac, Anja.; Savic, M.; Emala, C.; Cook, J.M.; Ernst, M., Mol. Pharmacology, 00,0000-0000 (2017).

Alleviation of Multiple Asthmatic Pathologic Features with Orally Available and Subtype Selective GABAA Receptor Modulators”, Forkuo, G.S.; Nieman, A.N.; Yuan, N.; Kodali, R.; Yu, O.B.; Zahn, N.M.; Jahan, R.;  Li, G.; Stephen, M.R.; Guthrie, M.L.; Poe, M.M.; Hartzler, B.; Harris,T.W.; Yocum, G.T.; Emala, C.; Steeber, D.; Stafford, D.C.; Cook, J.M.; Arnold,  L.A., Molecular Pharmaceutics, 00,0000-0000 (2017), DOI: 10.1021/acs.molpharmaceut.7b00183.

“Abuse-related Effects of Subtype-selective GABAA Receptor Positive Allosteric Modulators in an Assay of Intracranial Self-stimulation in Rats”, Schwienteck, K.L.; Li, G.; Poe, M.M.; Cook, J.M.; Banks, M.L.; Negus, S.S., Psychopharmacology, doi: 10.1007/s00213-017-4615-8 (2017).

“Further Evaluation of the Potential Anxiolytic Activity of Imidazo[1,5a] diazepin Agents Selective for α2/α3- Containing GABA Receptors”, Witkin, J.; Cerne, R.; Wakulchik, M.; Gleason, S,; Jones, T.; Li, G.; Arnold, A.; Li, Jun-Xu; Schkeryantz, J.; Methuku, K.; Cook, J.; Poe, M.M., Biochem. Behav., S0091-3057(17): 30088-6. doi: 10.1016/j.pbb.2017.04.009 (2017).

“Identification of Staphylococcus aureusCellular Pathways Affected by the Stilbenoid Lead Drug SK-03-92 Using a Microarray” Antibiotics 20176(3), 17; Link

“Concise Total Synthesis of (−)-Affinisine Oxindole, (+)-Isoalstonisine, (+)-Alstofoline, (−)-Macrogentine, (+)-Na-Demethylalstonisine, (−)-Alstonoxine A, and (+)-Alstonisine” Stephen, M. R..; Rahman, M. T.; Tituveedhula, VVNPB.; Fonseca, G. O.; Deschamps, J. R.; Cook, J. M., Chem. Eur. J. 201723, 15805.


“Total Synthesis of Sarpagine-Related Bioactive Indole Alkaloids” Rahman, M. T.; Deschamps, J. R.; Imler, G. I.; Cook, J. M., Chem. Eur. J. 201824 (10)2354–2359.

“Design and Synthesis of Novel Deuterated Ligands Functionally Selective for the γ-Aminobutyric Acid Type A Receptor (GABAAR) α6 Subtype with Improved Metabolic Stability and Enhanced Bioavailability” Knutson, D. E. et al., J. Med. Chem. 2018, ASAP,

Group Pictures

GROUP PHOTO ARCHIVE (hover cursor over photo for caption) Faculty of the year (2016-2017) award goes to Dr. Cook Dr. Cook receiving the award from Mark. 05-23-2017 Professor Kishi, Professor Cook and Professor Sosnovsky (98 years old) at Lunch March… Read More